中皮腫練習エッセンシャル胸膜中皮などの事実しばしば並んで体腔を伴う悪性

中皮腫

練習エッセンシャル
胸膜中皮などの事実しばしば並んで体腔を伴う悪性腫瘍は悪性中皮腫として知られ、腹膜、心膜、および睾丸、（下の写真参照します）。アスベスト、アスベストおよびクロシドライトアモサイトと呼ばれるアスベストの特に角閃石のタイプは、主に中皮腫悪性胸膜の病因に関連する発癌性です。



徴候と症状
胸膜中皮腫の悪性腫瘍の最も一般的なプレゼンテーションでnonpleuritic息と胸の痛みの症状の息切れは、患者の百分の60から90に発生するのは、少なくとも1があります。次のように一般的に関連するその他の症状：

胸部不快感
胸膜痛
易疲労性
発熱
汗をかきます
減量
身体検査では、胸水の検出は、通常、入力と聴診時に認識されています。患者はまた、症状がない場合があり、胸水の証拠は身体検査時や胸部X線検査によってつまずくを指摘しません。

診断します
からかわ

穿刺後に落ちた胸水の発現と胸膜中皮腫の患者の90％以上
一般的に、これらの知見は、 50％）、

管理
現在、治療が標準とみなされません。悪性中皮腫の管理のための治療の選択肢は、以下のものが挙げられます：

手術（合理的な疾患は胸膜腔に限定されている場合）
化学療法[2,3]
放射線（患者の50％において胸痛および胸壁転移の有意な軽減を提供）
集学治療
一般的に使用される化学療法レジメンは、次のとおりです。

シスプラチン - 単独療法のための基準
シスプラチン/ペメトレキセド
ペメトレキセド/ゲムシタビン - シスプラチンを取ることができない患者のために
一人でペメトレキセド
シスプラチン/ゲムシタビン

Kết quả (Anh) 1:

MesotheliomaEssential practiceMalignant tumors such as pleural mesothelioma facts often lined up the body cavity is known as malignant mesothelioma, peritoneum, pericardium, and testicles, (see the lower picture). Asbestos, asbestos and asbestos crocidolite AMO site called particularly amphibole type is primarily associated with the etiology of pleural mesothelioma with malignant cancer of.Signs and symptomsIn the most common presentation of malignant pleural mesothelioma shortness of breath nonpleuritic chest pain symptoms that occur to 90 from 60-100 minutes of at least 1. Following other commonly associated symptoms:Chest discomfortPleuritic painFatiguabilityFeverSweatWeight lossIn the physical examination, the detection of pleural effusion is usually recognized input and stethoscope. Patients also may cause no symptoms, stumbles during the physical examination, chest x-ray evidence of the pleural effusion is not pointed out.The diagnosis ofTeasedMore than 90% of patients with pleural mesothelioma pleural puncture droppedIn General, these findings are < 1000, with normal levels of some of the WBC / ml erythrocytes, high protein levels, and lactate dehydrogenase and diagnosis for pleural effusionCytology of pleural effusion is diagnosed in only 32% of patients, 56% is the recommended detection.FISH to distinguish from reactive Mesothelial cells of patients with malignant mesothelioma is 79% sensitivity [1].Thoracoscopic biopsy GuideOnly cases of mesothelioma have been proposedIn 98% of cases diagnosedThe preparation of stained biopsy diagnostic tool in patients with malignant mesothelioma most is worth. The differential diagnosis of malignant mesothelioma from adenocarcinoma of the features include:Acid - Schiff staining periods of negative results, mucicarmine stains, carcinoembryonic Antigen, and Leu-M1And calretinin, vimentin, anti-Cytokeratin antibody positiveBiomarkers in serumSoluble mesothelin (see current bio-markers)Causes of megakaryocytesCXRFindings of malignant pleural mesothelioma include one or more of the following.Spread of the diaphragmNodular thickening of the pleuraReduce the related breast sizeTransparency radiation, pleural and sheet packagingSo opacities of the main part of the pleura and Komuro exudate (patients > 50%),ManagementCurrently, the standard treatment is considered. For the management of patients with malignant mesothelioma treatment options that include:Surgery (if a reasonable disease only in the chest cavity)Chemotherapy [2, 3]Radiation (in 50% of patients provided significant relief of chest pain and chest wall metastasis)Multidisciplinary treatmentThe commonly used chemotherapy regimens are as follows.Cisplatin - based therapy forCisplatin and pemetrexedPemetrexed and Gemcitabine - for patients who can't take the cisplatinPemetrexed is oneCisplatin/Gemcitabine

Kết quả (Anh) 2:

Mesothelioma practice Essential malignant tumors with the fact often lined body cavity such as the pleural mesothelioma is known as mesothelioma malignancy, peritoneum, pericardium, and testicular, (see photo below). Asbestos, in particular type of amphibole asbestos, called the asbestos and crocidolite amosite is carcinogenic primarily related to the pathogenesis of mesothelioma malignant pleural. Signs and symptoms most in the general presentation of the symptoms of the pain of nonpleuritic breath and chest shortness of malignant tumors of pleural mesothelioma is, to occur from the patient's hundredths of 60 to 90, there is at least 1. Commonly associated with other symptoms as follows: chest discomfort pleurodynia easy fatigability fever and sweat weight loss in the physical examination, the detection of the pleural effusion is, usually, has been recognized at the time of auscultation and input. Patients also may have no symptoms, evidence of pleural effusion does not point out the stumble by physical examination or when a chest X-ray examination. To diagnose teased more than 90% of the patients of expression and pleural mesothelioma of pleural effusion, which fell after the puncture In general, these findings, of <1000 WBC / ml, some of the red blood cells, high protein levels, and lactic acid is a pleural effusion for the normal level and the diagnosis of dehydrogenase, pleural effusion cells are diagnosed in only 32% of the patients, the detection of 56% is recommended from reactive mesothelial cells in the leachate, the malignant mesothelioma FISH for to distinguish, [1] with a sensitivity of 79% thoracoscopic guided biopsy only if the mesothelioma has been proposed diagnosis in 98% example is stained biopsy is a diagnostic tool, of malignant mesothelioma the most valuable and ready for some in the middle. The differential diagnosis of the features of malignant mesothelioma from adenocarcinoma, are as follows. Acid - a negative result of Schiff staining period, mucicarmine dirt, carcinoembryonic antigen, and Leu M1 calretinin, vimentin, cytokeratin positive and biomarkers in serum (see the current biomarker) soluble mesothelin of megakaryocytes occurrence factor CXR findings of malignant tumors of pleural mesothelioma, will include one or more of the following. Spread of the diaphragm nodular thickening of the pleura to reduce the size of the associated breast radiolucent, sheet-like packaging of pleural effusion with opacity and Komuro of the main part of the pleura (of patients> 50%), management currently, treatment and standard not considered. The treatment of choice for the management of malignant mesothelioma, will include the following: surgery (if reasonable disease is limited to the pleural cavity) chemotherapy [2,3] radiation (50 patients a significant reduction in chest pain and chest wall metastasis offer) in% combined modality treatment chemotherapy regimen to be used in general is as follows. Cisplatin - the criteria for the monotherapy cisplatin / pemetrexed pemetrexed / gemcitabine - for patients who can not take the cisplatin pemetrexed alone cisplatin / gemcitabine

Kết quả (Anh) 3:

MesotheliomaEssen financial practiceThe pericardium, peritoneal and pleural mesothelioma testicular, often in the malignant tumor with effusion and malignant mesothelioma, (see picture below). Asbestos, asbestos and asbestos and is especially called クロシドライトアモサイト amphibole types, is mainly related to the pathogenesis of malignant pleural mesothelioma.Signs and symptomsThe nonpleuritic shortness of breath and chest pain symptoms of malignant pleural mesothelioma is the most common presentation, the patient of 60 to 90 percent of the at least one. Other common symptoms related to the following:Chest discomfortPleuritic painFatigue propertyExothermic reactionSweat.Weight lossOn physical examination, detection of pleural effusion, usually, when the input is recognized. In addition, the patient may have no symptoms, and physical evidence of pleural effusion in chest X-ray inspection for X by based on said.The diagnosis.FunThe expression of pleural effusion and malignant pleural mesothelioma in 90 patients after more than punctureIn general, these findings WBC 1000 ml of red blood cells, the number of the high protein level, and normal levels of lactate dehydrogenase in pleural effusion for diagnosisPleural effusion cytology in the diagnosis of patients with only 32%, 56 is recommendedFrom reactive mesothelial cells in the FISH to distinguish malignant mesothelioma, having 1 to 79% of sensitivityThoracoscopic biopsy guideOnly if the proposed mesotheliomaIn the case of 98% diagnosisThe diagnostic tools, stained biopsy in malignant mesothelioma is the most valuable. From the features of malignant mesothelioma, adenocarcinoma in the differential diagnosis.Negative for PAS staining, acid mucicarmine period, carcinoembryonic antigen, and Leu M 1Calretinin, cytokeratin, vimentin positiveBiomarkers in serumSoluble mesothelin (see the current biomarkers.Factors of megakaryocyteCXRThe findings of malignant pleural mesothelioma, include one or more.The spread of the diaphragmNodular thickening of pleuraTo reduce the size of the chestRadiation permeable sheet, packaging of pleuraThe main part of the pleural effusion of turbidity and 50 per cent of patients (Komuro.ManagementAt present, the treatment is not seen as a standard. Treatment options for the management of malignant mesothelioma of the following:A rational operation when the disease is confined to the pleural cavity.Chemotherapy, [2] [3]Radiation and significant chest pain in the patients of 50% reduction.Multidisciplinary treatmentChemotherapy regimens commonly used are as follows.Standards for cisplatin alone.Cisplatin and pemetrexedFor patients who are unable to take the pemetrexed and cisplatin and gemcitabinePemetrexed aloneCisplatin and gemcitabine