放射線治療のIMPRINT中皮腫の治療医師は、放射線手順がアクティブリ

放射線治療のIMPRINT中皮腫の治療



医師は、放射線手順がアクティブリビングと二次性腫瘍の発現を有する患者の生活の質を向上させるために、肺温存手術に安全かつ効果的に組み合わせることが可能で確認しました組織。

洗練の十年後、中皮腫のための専門センターの数が少ない最近の進展の一環として、強度変調処理（IMPRINT）を使用して、胸膜放射線であります集学的治療に有用です。

放射線腫瘍医博士ケネス「我々は、すべてのセンターが中皮腫の治療の経験が今自分の武器庫に入れて別の技術、としてこれを検討する持っていることを願っています」マウント・シナイ医療センターのローゼンツヴァイクはAsbestos.com言いました。 「技術は、我々は、これらの患者を助けるために必要なものに追いついたことは興味深いです。」

ローゼンツヴァイクは、20年に中皮腫を治療しました。彼は、最近の多施設への早期貢献者、放射線肺炎（RP）、有害な副作用の可能性の受け入れの低金利を発見したIMPRINT研究の第II相でした。 Journal of Clinical Oncology誌は、6月に研究を発表しました。

研究では、ローゼンツヴァイクは前に働いていたニューヨークでのがんセンターで患者を含めて、ヒューストンのMDアンダーソンがんセンター。

肺温存手術を支援

これらの知見は、専門家の間で信頼関係を強化すべきますます中皮腫の肺温存/剥離（P / D）が最も候補胸膜肺全摘術の手術の詳細のために良い選択であること胸膜切除（EPP） 、肺全体を除去します。

従来の放射線EPP領域後の再発のリスクを減少させるのに過去の成功の技術が、外科手術後の肺への毒性を伴わずに同様の投与量レベルの安全な方法を提供することで過度のが困難です芸術P / D.

外科医は、彼らが肺を削除しなかった、と患者がその後の放射線を必要としない場合は、それを効果的に行うための方法はありませんでした。それは挑戦であるということであったことを「一つの問題どのように我々が通過しようとした「ローゼンツヴァイクは語りました。 「しかし、今私は、外科医がより限定された切除（P / D）を製造する懸念がある場合、我々はこの時点でそれを和らげることができると思います。」

試験では、ペメトレキセドとシスプラチンまたはカルボプラチン化学療法を受けた患者45人で始まりました。それらの十八は、化学療法の合併症、疾患の進行の対象となりませんか、手術や放射線治療を拒否します。

研究者は、残りの参加者とIMPRINT相に始めています。

副作用管理のレート

八適格患者は肺炎グレード2またはグレード3放射線、肺炎のような症状が作成条件を開発しています。すべての8、しかし、コルチコステロイド治療後の迅速な回復。放射線肺炎の無等級4または5例ません。

21人の患者は、P / Dの手術を受けました。他の6つが遮断されるべきではないとみなされた化学療法と放射線療法の間に手術を持っていませんでした。

すべての患者の平均無増悪生存期間および生存率は、それぞれ12.4ヵ月、23.7ヵ月でした。年に80％と2年間で59パーセントの外科患者全体の生存率。

一年生存率は削除することはできません病気とのそれらのための74パーセントでしたが、2年生存率は25％に低下します。

化学療法応答は著者らによると、生存率に大きな役割を果たしています。

化学療法に少なくとも部分的応答とのそれらのための100％の生存率1年と53パーセント2年生存率があります。

"我々は、手術後の放射線が腫瘍が返されるために可能性を小さくすることを知っているが、肺がまだそこにあるときにそれを安全に提供することは非常に困難であり、「ローゼンツヴァイクは語りました。 「10-12年間で、我々はそれを安全に配信するために、この技術に取り組んできました。これは非常に心強いです。」

ローゼンツヴァイクは、研究成果が技術IMPRINTを包含するより多くのがんセンターを促すものと考えております。

彼はまた、次のステップは大きく、無作為化、多施設試験はさらに説得力のあることと、最終的に中皮腫の患者のための治療の選択肢を改善すると考えています。

「放射線治療が最終でない場合でも、それはまだ我々は最小限の副作用で患者に質の時間のかなりの量を得ることができるかどうか良いことですが、 "と彼は言いました。 「それは、物事が良くなっている兆候です。」

Kết quả (Anh) 1:

IMPRINT radiation therapy mesothelioma treatmentThe organization can safely and effectively combine lung-sparing surgery doctors to improve the quality of life of patients with active living and secondary tumors of the radiation procedure, and confirmed.Using intensity-modulated treatment (IMPRINT) as part of a sophisticated 10 years later, the Centre of expertise for the mesothelioma a small number of recent developments, in the pleura radiation therapy is useful.Radiation oncologist Dr. Kenneth "we is the center of all mesothelioma treatment for now their arsenal into another technology, and hope to have, consider this" Asbestos.com said Rosenzweig of Mount Sinai Medical Center. "Is interesting to technology helps these patients, we caught up with what you need. 」Rosenzweig, 20 years was treating mesothelioma. His IMPRINT research have found acceptance of the possibility of the early contributors to the recent multicenter, radiation Pneumonitis (RP), harmful side effects low interest rates no. did the phase II. Journal of Clinical Oncology Journal announces a study in June.Research, Rosenzweig works ago the cancer in New York City were patients at the Center, including Houston's M.D. Anderson Cancer Center.Support the lung-sparing surgeryThese findings should strengthen trust among professionals increasingly mesothelioma lung preservation / detachment (P/D) for details of candidate extrapleural pneumonectomy surgery best option removes extrapleural resection (EPP), the entire lung.By providing a safe dosage levels as well as for technical success in the past to reduce the risk of recurrence after conventional radiation EPP area without any toxicity to the lungs after surgery for excessive is a difficult art P/D.There is no way for the surgeon, they did not remove the lung patient requires radiation and then not do it effectively. That was challenges is that "one problem how it tries to pass we will see, Rosenzweig said. "But I think now I have to manufacture the surgeon more limited resection (P/D) concerns, we can relieve it at this point. 」Started in patients receiving pemetrexed and cisplatin or carboplatin chemotherapy trials, 45. 18 of them will not be eligible for chemotherapy complications, disease progression, or refuse surgery or radiation therapy.Researchers has begun to IMPRINT phase with the remaining participants.Rate of side effects management8 eligible patients is pneumonia grade 2 or grade 3 radiation and pneumonia-like symptoms and develops to create. All the 8, but a speedy recovery after corticosteroid treatment. Radiation Pneumonitis unrated 4 or 5 does not.21 patients were P/D surgery. Did not have the surgery during the radiotherapy and chemotherapy should cut off the other six, was never considered.All patients average progression-free survival and the survival rate was 12.4 months, was 23.7 months. 80% in the year and survival of the entire surgical patients of 59 percent over two years.Year survival rates cannot be removed was 74 percent for those with the disease, the two-year survival rate drops to 25% the.Chemical therapy response, according to the authors plays big role in survival.Chemotherapy at least survival rate of 100% for those with partial response of survival one year and 53 percent two years."It provides safety when the lung is still there, but know that we returned the tumor radiation after surgery to reduce potential very difficult, and," Rosenzweig said. "For 10-12 years, we are delivering it safely to have been working on this technology. This is very encouraging. 」Rosenzweig is to embrace technology IMPRINT research more cancer we believe call center.I think that he also, next step is larger, randomized, multicenter trial more eloquent and ultimately improve for patients of mesothelioma treatment options."Whether or not, even if radiation therapy is not final it yet we get a fair amount of quality time in patients with minimal side effects can be a good thing," and he said. "It is a sign things are getting better. 」

Kết quả (Anh) 2:

Treatment of mesothelioma IMPRINT radiotherapy physician, in order to improve the quality of life of patients radiation procedures have expression of active living and secondary tumors, can be combined safely and effectively in the lung sparing surgery in was confirmed organization. After ten years of refinement, as part of the recent developments a small number of specialized center for mesothelioma, using the intensity modulation processing (IMPRINT), it is useful to have it multidisciplinary treatment in the pleural radiation. Radiation oncologist Dr. Kenneth "We are, all of the centers of the treatment of mesothelioma experience their own armory to put another in the now technology, as we hope that you have to consider this," Mount Sinai medical Center of Rosenzweig told Asbestos.com. "Technology, we shall be caught up in what you need to help these patients is interesting." Rosenzweig has to treat mesothelioma in 20 years. He, early contributors to the recent multi-center, radiation pneumonitis (RP), was the harmful side effects of the possibility of Phase II of the IMPRINT study that found the low interest rates of acceptance. The Journal of Clinical Oncology has published a study in June. In the study, Rosenzweig, including the patient in the Cancer Center in New York who worked on before, Houston's MD Anderson Cancer Center. Support the lung-sparing surgery these findings, experts between in the lungs of mesothelioma increasingly should strengthen the trust relationship sparing / peeling (P / D) for the details of most candidate pleural pneumonectomy surgery pleurectomy it is a good choice (EPP), to remove the entire lung. Technology of the past success in reducing the risk of recurrence after conventional radiation EPP area is, after surgery to lung toxicity accompanied not to the same dose level secure way excessive to provide the is a difficult art P / D. surgeon, if they did not remove the lung, and the patient does not require subsequent radiation, there was no way to do it effectively. It spoke of the "Rosenzweig how we are" one of the problems was trying to pass the thing was that it is a challenge. "But, now I, resection the surgeon has been more limited (P / D ) If there is a concern that the production of, we think it is possible to relieve it at this point. " in the test, it began with 45 patients who received pemetrexed and cisplatin or carboplatin chemotherapy. Those eighteen, the complications of chemotherapy, do not become the object of the progression of the disease, it will refuse to surgery and radiation therapy. Researchers are beginning to the rest of the participants and the IMPRINT phase. Rate of side effects management eight eligible patients have pneumonia grade 2 or grade 3 radiation, symptoms such as pneumonia developed to create conditions. All of 8, however, rapid recovery after corticosteroid therapy. No grade of radiation pneumonitis 4 or does Mase five cases. 21 patients were undergoing surgery of the P / D. The other six, but I did not have the surgery during the chemotherapy and radiation therapy that was considered not to be cut off. The average progression-free survival and survival rate of all patients, respectively, 12.4 months, was 23.7 months. 80% and 59% survival rate of the entire surgical patients in the two years to the year. Although one year survival rate was 74 percent for those with the can not disease be removed, the 2-year survival rate drops to 25 percent. Chemotherapy response, according to the authors, has played a major role in the survival rate. There is a 100% survival rate one year and 53 percent two-year survival rate for those with at least a partial response to chemotherapy. "We know that radiation after surgery to reduce the potential for tumor is returned, to provide it safely when the lung is still in there is very difficult," Rosenzweig was told. "10 -.. in 12 years, we have to deliver it safely, we have been working on this technology which is very reassuring," Rosenzweig, the research results technology IMPRINT It believed to encourage a lot of cancer centers than include. He also, the next step is large, we believe randomization, and that the multi-center study is that there is still compelling, and ultimately to improve the treatment options for mesothelioma patients. Even if "radiation therapy is not the last, it is still we are is that whether good or can get a significant amount of quality time in the patient with a minimum of side effects," he said. "It is a sign that things are getting better."

Kết quả (Anh) 3:

IMPRINT mesothelioma treatment of radiation therapyThe doctor, the radiation procedures and active living with tumor development to improve the quality of life of the patients, the organization has confirmed it is possible to combine the safely and effectively in lung preservation.After a decade of sophistication as a part of the recent progress of the small number of professional center for mesothelioma, and the processing IMPRINT intensity modulation), which is useful in the treatment of radiation in the pleura.We are a radiation oncologist Dr. Kenneth ", the technology of mesothelioma treatment of another in his Arsenal now all Rosenzweig, center of Mount Sinai Medical Center, hope to have this as a study" was Asbestos com says. "Our technology is needed to help these patients is interesting that came up with."Rosenzweig, mesothelioma treatment for 20 years. His early contributions to the recent multicenter, radiation pneumonitis (RP), the phase of the study IMPRINT II was found low interest rates to accept the possibility of adverse side effects. The Journal of Clinical Oncology magazine published the study in June.In the study, Rosenzweig in front of New York working in cancer patients, including Houston MD Anderson Cancer Center.Lung preservation operation supportThese findings among specialists should be strengthened more and more trust relationship of mesothelioma and lung preservation, separation and D pleurectomy P) most of the candidates of extrapleural pneumonectomy for detailed operation is a good choice, EPP) is removed, the whole lung.Past success skills after conventional radiation EPP region in order to decrease the risk of recurrence, D P art and to provide a safe dose level, as well as how difficult is excessive after surgery without pulmonary toxicity inThe surgeon, they did not remove the lungs, and when the patient does not need radiation after that, there was no way to carry out it effectively. We were trying to pass that "it is a challenging problem how to speak" Rosenzweig. "But now I, is limited by the surgeon (P and D) when there is a manufacturing concern, we are at this point that can relieve it."The trial began in 45 patients who received cisplatin and pemetrexed and carboplatin chemotherapy. Of those, the complication of chemotherapy, and the progress of the disease, surgery or radiation therapy.The rest of the study participants and began to IMPRINT phase.Management of adverse reaction rateRadiation pneumonia patients with eight grade or grade 2 grade 3, developed symptoms of preparation conditions, such as pneumonia. All, however, rapid recovery after corticosteroid treatment. No cases of radiation pneumonia without grade 4 or 5.21 patients received surgery and P D. It was considered that the other six blocks to be chemotherapy and radiotherapy during operation do not have.The average survival rate of progression-free survival of patients, and all 12.4 each month, 23.7 months. In two years, and 80 percent of the whole surgery patient"s survival rate.One year can not delete the survival rate in 74 percent of those with the disease, and for two years survival rate was 25% reduction.The response of chemotherapy by authors, the survival rate has played a major role.Chemotherapy on survival rate of at least 100% for those with partial response 53 percent a year and two years survival rate."We know that it is possible for the operation is returned after the radiation oncology is small when the lung is still there and it is very difficult to provide safe," Rosenzweig said. In 10 years, we have to make it safe, have been working on this technology. This is very encouraging. "Rosenzweig, research results will stimulate more and more including cancer center IMPRINT technology.He is also, the next step is a large, randomized, multicenter studies more persuasive, and thinking for patients with mesothelioma treatment options, and finally to improve."But if not, radiation therapy